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KMID : 1103720140710050201
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Journal of the Korean Society of Radiology
2014 Volume.71 No. 5 p.201 ~ p.204
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Osmotic Demyelination Syndrome with Recent Chemotherapy in Normonatremic Patient: A Case Report
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Lee Sung-Jae
Baek Hye-Jin
Jung Hyun-Kyung
Kim Seon-Jeong
Lee Ye-Da-Un
Lee Kwang-Hwi
Ryu Ji-Hwa
Kim Hong-Dae
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Abstract
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Osmotic demyelination syndrome (ODS), an acquired demyelinating condition of the central pons and/or other regions of the brain, is frequently associated with rapid correction of hyponatremia. There are several reports of ODS in other clinical setting such as malnutrition, alcoholism, transplantation, malignancy, and chronic debilitating illness. However, cases of ODS associated with chemotherapy have not been frequently reported. Here, we describe a case of ODS in a normonatremic patient recently underwent chemotherapy for colon cancer. The diagnosis was confirmed by MRI showing a typical T2 hyperintensity in the central pons. This case suggests that ODS is not always associated with hyponatremia and that ODS can have a favorable clinical and radiologic prognosis.
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KEYWORD
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Osmotic Demyelination Syndrome, Central Pontine Myelinolysis, Normonatremia, Chemotherapy
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